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Webster 1913 Edition

Adj.

Having a large head, like a buffalo; dull; stupid; blundering.

[Obs.]

So fell this

buffle-headed

giant.

Gayton.

Adj.

Having a large head, like a buffalo; dull; stupid; foolish.

buffle-headed ‎(comparative more buffle-headed, superlative most buffle-headed)

(obsolete) Having a large head, like a buffalo's.
(obsolete) dull; stupid; blundering
So fell this buffle-headed giant. — Gayton.